NXT1 (p15) is a crucial cellular cofactor in TAP-dependent export of intron-containing RNA in mammalian cells.

@article{Guzik2001NXT1I,
  title={NXT1 (p15) is a crucial cellular cofactor in TAP-dependent export of intron-containing RNA in mammalian cells.},
  author={Brian W Guzik and Lyne L{\'e}vesque and Swati Prasad and Y C Bor and Ben E. Black and Bryce M. Paschal and David Rekosh and M L Hammarskj{\"o}ld},
  journal={Molecular and cellular biology},
  year={2001},
  volume={21 7},
  pages={2545-54}
}
TAP, the human homologue of the yeast protein Mex67p, has been proposed to serve a role in mRNA export in mammalian cells. We have examined the ability of TAP to mediate export of Rev response element (RRE)-containing human immunodeficiency virus (HIV) RNA, a well-characterized export substrate in mammalian cells. To do this, the TAP gene was fused in frame to either RevM10 or RevDelta78-79. These proteins are nonfunctional Rev mutant proteins that can bind to HIV RNA containing the RRE in vivo… CONTINUE READING

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