NUT rearrangement in undifferentiated carcinomas of the upper aerodigestive tract.

@article{Stelow2008NUTRI,
  title={NUT rearrangement in undifferentiated carcinomas of the upper aerodigestive tract.},
  author={Edward B. Stelow and Andrew M Bellizzi and Krishan L. Taneja and Stacey E. Mills and Robin D Legallo and Jeffery L. Kutok and Jon C Aster and Christopher A French},
  journal={The American journal of surgical pathology},
  year={2008},
  volume={32 6},
  pages={828-34}
}
BACKGROUND Undifferentiated carcinomas of the upper aerodigestive tract (UCUAT) occur most frequently within the nasopharynx and are most often associated with infection by Epstein-Barr virus (EBV) (WHO undifferentiated nonkeratinizing squamous cell carcinoma). An unusual group of aggressive carcinomas are characterized by translocations that involve Nuclear Protein in Testis (NUT), a novel gene on chromosome 15. In about two-thirds of cases, NUT is fused to BRD4 on chromosome 19. These tumors… CONTINUE READING

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Nasopharyngeal carcinoma

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