NUP98 gene rearrangements and the clonal evolution of chronic myelogenous leukemia.

@article{Ahuja2001NUP98GR,
  title={NUP98 gene rearrangements and the clonal evolution of chronic myelogenous leukemia.},
  author={Harish G. Ahuja and Leslie L Popplewell and Lucene Tcheurekdjian and Marilyn L. Slovak},
  journal={Genes, chromosomes & cancer},
  year={2001},
  volume={30 4},
  pages={410-5}
}
The role of the BCR-ABL fusion gene in the pathogenesis of the chronic phase of chronic myelogenous leukemia (CML) has been well established. Several additional genetic changes have been reported to occur, at varying frequencies, during disease progression to "accelerated" and "blast crisis" phases. The NUP98 gene localized to chromosome band 11p15 has been found at the breakpoints of several distinct chromosomal translocations in patients with both de novo and therapy-related myelodysplastic… CONTINUE READING

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