NUP37 silencing induces inhibition of cell proliferation, G1 phase cell cycle arrest and apoptosis in non-small cell lung cancer cells.

  title={NUP37 silencing induces inhibition of cell proliferation, G1 phase cell cycle arrest and apoptosis in non-small cell lung cancer cells.},
  author={Lianglong Huang and Tao Wang and Fu-wen Wang and Xiaoyi Hu and Guoxiang Zhan and X.-B. Jin and Li-Chen Zhang and Yuping Li},
  journal={Pathology, research and practice},

Nucleoporin 37 promotes the cell proliferation, migration, and invasion of gastric cancer through activating the PI3K/AKT/mTOR signaling pathway.

NUP37 promoted malignant behavior of gastric cancer cells including invasion, proliferation, and migration through activating the PI3K and its downregulated signaling pathway, indicating that NUP37 might become a novel prognostic target for further Gastric cancer therapy.

RSPH14 regulates the proliferation, cell cycle progression, and apoptosis of non‐small cell lung cancer cells

The results of the present study suggest that RSPH14 may be a promising prognostic factor and therapeutic target for NSCLC.

Pan-cancer analysis reveals NUP37 as a prognostic biomarker correlated with the immunosuppressive microenvironment in glioma

The results suggest that NUP37 is a potential oncogene and prognostic biomarker in glioma and pan-cancer and are resistant to several anti-cancer drugs.

Demethylation at enhancer upregulates MCM2 and NUP37 expression predicting poor survival in hepatocellular carcinoma patients

Minichromosome maintenance complex component 2 (MCM2) and nucleoporin 37 (NUP37) were overexpressed in human HCC tissues and hepatoma cell lines and Demethylation at an enhancer of MCM2 gene was a common event in patients with HCC, which significantly negatively correlated with MCM 2 and NUP37 mRNA expression.

Evaluation of Oncogene NUP37 as a Potential Novel Biomarker in Breast Cancer

The multiple bioinformatics and experimental analysis help provide a comprehensive understanding of the roles of NUP37 as a potential marker for diagnosis and prognosis and as a novel therapeutic target in breast cancer.

Identification of Co-Expression Modules and Genes Associated With Tumor Progression in Oral Squamous Cell Carcinoma

Five hub genes were identified to be relevant to oral cancer from the molecular level and the clinical level and could shed light on the improvement of patients’ overall survival and prognosis, which needs further analysis in the future.

Identification and validation of a glycolysis-related gene signature for depicting clinical characteristics and its relationship with tumor immunity in patients with colon cancer.

The glycolysis-related gene model could provide the basis for potential early individualized treatment and immunotherapy strategies in colon cancer patients and was a reliable predictive tool for the prognosis of colon cancer.

Glycolysis Changes the Microenvironment and Therapeutic Response Under the Driver of Gene Mutation in Esophageal Adenocarcinoma

It is demonstrated that glycolysis could influence the microenvironment and drug therapeutic response in EAC and high tumor mutation burden (TMB) was associated with better immunotherapeutic response.

Significantly high expression of NUP37 leads to poor prognosis of glioma patients by promoting the proliferation of glioma cells

The main purpose of this study is to reveal the relationship between NUP37 and prognosis or clinical characteristics of glioma patients.

m6A Modification Mediates Mucosal Immune Microenvironment and Therapeutic Response in Inflammatory Bowel Disease

Findings indicate that m6A modification may affect immune infiltration and therapeutic response in IBD, and assesses the expression of m 6A phenotype-related hub genes might guide the choice of IBD drugs and improve the prediction of therapeutic response to anti-TNF therapy.



NUP37, a positive regulator of YAP/TEAD signaling, promotes the progression of hepatocellular carcinoma

It was found NUP37, the component of NPC, significantly up-regulated in HCC clinical samples and mouse model and suggested that NUP 37 might be a promising therapeutic target.

Whole transcriptome sequencing identifies tumor-specific mutations in human oral squamous cell carcinoma

The finding of known tumor genes detected proves of the utility of RNA-Seq in mutation screening, and functional analysis of genes detected here would help understand the molecular mechanism of OSCC.

Ectopic Activation of Germline and Placental Genes Identifies Aggressive Metastasis-Prone Lung Cancers

An ectopic gene expression signature associated with a subset of highly aggressive tumors, which predicted poor prognosis independently of the TNM (tumor size, node positivity, and metastasis) stage or histological subtype is identified.

Gene Expression-Based Classification of Non-Small Cell Lung Carcinomas and Survival Prediction

The gene signatures identified are promising tools for histo-pathological classification of non-small cell lung cancer, and may improve the prediction of clinical outcome.

Epidermal Growth Factor Receptor Tyrosine Kinase Defines Critical Prognostic Genes of Stage I Lung Adenocarcinoma

It is re-emphasized that EGF signaling status in cancer cells underlies an aggressive phenotype of cancer cells, which is useful for the selection of early-stage lung adenocarcinoma patients with a poor prognosis.

Comparing and contrasting predictive biomarkers for immunotherapy and targeted therapy of NSCLC

The era of personalized medicine for advanced-stage non-small-cell lung cancer (NSCLC) began when biomarker-based evidence of molecular pathway and/or oncogene addiction of the tumour became

Molecular basis for Nup37 and ELY5/ELYS recruitment to the nuclear pore complex

The basic scaffold underlying the NPC, the species-specific scaffold nucleoporin Nup37 and ELY5/ELYS is characterized and an orientation of the Y-complex relative to the pore membrane is proposed, consistent with the lattice model.

Structural biology of nucleocytoplasmic transport.

The molecular mechanisms underlying nucleocytoplasmic transport as they have been revealed by structural studies of the receptors and regulators in different steps of transport cycles are described.