NUMBL interacts with TRAF6 and promotes the degradation of TRAF6.

@article{Zhou2010NUMBLIW,
  title={NUMBL interacts with TRAF6 and promotes the degradation of TRAF6.},
  author={Li Yang Zhou and Qi Ma and Huili Shi and Keke Huo},
  journal={Biochemical and biophysical research communications},
  year={2010},
  volume={392 3},
  pages={409-14}
}
Tumor necrosis factor-associated factor 6 (TRAF6) is an essential adaptor protein for IL-1R or TLR-mediated NF-kappaB signaling pathway activation. In previous work we have found NUMBL interacts with TAB2 and negatively regulates NF-kappaB signaling pathway. Here, we report that NUMBL directly binds to TRAF6 in vivo and in vitro. NUMBL down-regulates TRAF6 protein level and shortens its half-life. Furthermore, knockdown of NUMBL significantly increases endogenous TRAF6 protein level in the… CONTINUE READING
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