NUMB suppression by miR-9-5P enhances CD44+ prostate cancer stem cell growth and metastasis

  title={NUMB suppression by miR-9-5P enhances CD44+ prostate cancer stem cell growth and metastasis},
  author={Xuan Wang and Jiong Cai and Lei Zhao and Dejun Zhang and Guojie Xu and Jianli Hu and Tao Zhang and Min Jin},
  journal={Scientific Reports},
Experimental and clinical studies over the past two decades have provided overwhelming evidence that human cancers, including prostate cancer (PCa), harbor cancer stem cells (CSCs) that sustain tumor growth, drive tumor progression and mediate therapy resistance and tumor relapse. Recent studies have also implicated NUMB as a PCa suppressor and an inhibitor of PCa stem cells (PCSCs); however, exactly how NUMB functions in these contexts remains unclear. Here, by employing bioinformatics… 

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