NUMB mediates the interaction between Wnt and Notch to modulate primitive erythropoietic specification from the hemangioblast

Abstract

During embryonic development, the establishment of the primitive erythroid lineage in the yolk sac is a temporally and spatially restricted program that defines the onset of hematopoiesis. In this report, we have used the embryonic stem cell differentiation system to investigate the regulation of primitive erythroid development at the level of the… (More)
DOI: 10.1038/cr.2008.176

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