NUMB controls p53 tumour suppressor activity

  title={NUMB controls p53 tumour suppressor activity},
  author={I. Colaluca and D. Tosoni and P. Nuciforo and Francesca Senic-Matuglia and V. Galimberti and G. Viale and S. Pece and P. P. D. Fiore},
  • I. Colaluca, D. Tosoni, +5 authors P. P. D. Fiore
  • Published 2008
  • Biology, Medicine
  • Nature
  • NUMB is a cell fate determinant, which, by asymmetrically partitioning at mitosis, controls cell fate choices by antagonising the activity of the plasma membrane receptor of the NOTCH family. NUMB is also an endocytic protein, and the NOTCH–NUMB counteraction has been linked to this function. There might be, however, additional functions of NUMB, as witnessed by its proposed role as a tumour suppressor in breast cancer. Here we describe a previously unknown function for human NUMB as a… CONTINUE READING
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