NUMB controls p53 tumour suppressor activity

@article{Colaluca2008NUMBCP,
  title={NUMB controls p53 tumour suppressor activity},
  author={I. Colaluca and D. Tosoni and P. Nuciforo and Francesca Senic-Matuglia and V. Galimberti and G. Viale and S. Pece and P. P. D. Fiore},
  journal={Nature},
  year={2008},
  volume={451},
  pages={76-80}
}
  • I. Colaluca, D. Tosoni, +5 authors P. P. D. Fiore
  • Published 2008
  • Biology, Medicine
  • Nature
  • NUMB is a cell fate determinant, which, by asymmetrically partitioning at mitosis, controls cell fate choices by antagonising the activity of the plasma membrane receptor of the NOTCH family. NUMB is also an endocytic protein, and the NOTCH–NUMB counteraction has been linked to this function. There might be, however, additional functions of NUMB, as witnessed by its proposed role as a tumour suppressor in breast cancer. Here we describe a previously unknown function for human NUMB as a… CONTINUE READING
    325 Citations
    A Numb–Mdm2 fuzzy complex reveals an isoform-specific involvement of Numb in breast cancer
    • 13
    • PDF
    Dynamic methylation of Numb by Set8 regulates its binding to p53 and apoptosis.
    • 69
    • Highly Influenced
    NUMB regulates the endocytosis and activity of the anaplastic lymphoma kinase in an isoform-specific manner
    • 2
    • PDF
    NUMB-ing down cancer by more than just a NOTCH.
    • 123
    Reciprocal repression between P53 and TCTP
    • 153

    References

    SHOWING 1-10 OF 43 REFERENCES
    Regulation of p53 stability by Mdm2
    • 3,147
    Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis
    • 460
    • PDF
    Mdm2 promotes the rapid degradation of p53
    • 4,004
    The Mdm2 Oncoprotein Interacts with the Cell Fate Regulator Numb
    • 144
    • PDF
    Numb Is an Endocytic Protein
    • 350
    • PDF
    Tumor surveillance via the ARF-p53 pathway.
    • C. Sherr
    • Biology, Medicine
    • Genes & development
    • 1998
    • 737
    • PDF