NUDT2 Disruption Elevates Diadenosine Tetraphosphate (Ap4A) and Down-Regulates Immune Response and Cancer Promotion Genes

@inproceedings{Marriott2016NUDT2DE,
  title={NUDT2 Disruption Elevates Diadenosine Tetraphosphate (Ap4A) and Down-Regulates Immune Response and Cancer Promotion Genes},
  author={Andrew S. Marriott and Olga Vasieva and Yongxiang Fang and Nikki A. Copeland and Alexander G McLennan and Nigel Jones},
  booktitle={PloS one},
  year={2016}
}
Regulation of gene expression is one of several roles proposed for the stress-induced nucleotide diadenosine tetraphosphate (Ap4A). We have examined this directly by a comparative RNA-Seq analysis of KBM-7 chronic myelogenous leukemia cells and KBM-7 cells in which the NUDT2 Ap4A hydrolase gene had been disrupted (NuKO cells), causing a 175-fold increase in intracellular Ap4A. 6,288 differentially expressed genes were identified with P < 0.05. Of these, 980 were up-regulated and 705 down… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 6 times over the past 90 days. VIEW TWEETS
5 Citations
178 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 178 references

Similar Papers

Loading similar papers…