NUDT15 p.R139C variant is common and strongly associated with azathioprine-induced early leukopenia and severe alopecia in Korean patients with various neurological diseases.

@article{Kim2017NUDT15PV,
  title={NUDT15 p.R139C variant is common and strongly associated with azathioprine-induced early leukopenia and severe alopecia in Korean patients with various neurological diseases.},
  author={Sun-Young Kim and Jin-Hong Shin and Jin-sung Park and Sa-Yoon Kang and Tai-Seung Nam and Jong Kuk Kim and K. Park and So-Young Huh and Ji Seon Oh and Boram Kang and Dae-Seong Kim},
  journal={Journal of the neurological sciences},
  year={2017},
  volume={378},
  pages={64-68}
}
Azathioprine (AZA)-induced leukopenia is a relatively common complication in Korean patients. In addition to variation in TPMT (thiopurine S-methyltransferase), the NUDT15 p.R139C variant was recently identified to have a strong association with AZA-induced leukopenia. We investigated these associations in Korean patients undergoing AZA treatment with various neurological diseases. Among 84 enrolled patients, 20 (23.8%; 7 early, 13 late) exhibited leukopenia. The NUDT15 p.R139C variant was… CONTINUE READING

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