NUCLEIC ACID AND PROTEIN SYNTHESIS DURING POLIOVIRUS INFECTION OF HUMAN CELLS.

@article{Holland1964NUCLEICAA,
  title={NUCLEIC ACID AND PROTEIN SYNTHESIS DURING POLIOVIRUS INFECTION OF HUMAN CELLS.},
  author={John J. Holland and Jennifer A Peterson},
  journal={Journal of molecular biology},
  year={1964},
  volume={8},
  pages={
          556-75
        }
}
Poliovirus infection of HeLa cells apparently prevents polymerization of host cell RNA on its DNA template, but most pre-existing host cell ribosomal RNA molecules remain intact during poliovirus replication. DNA-directed RNA synthesis catalysed by aggregate enzyme RNA polymerase was greatly inhibited in vitro in preparations from infected cells. The priming ability of DNA from infected cells was equal to that of normal cells when Escherichia coli RNA polymerase was employed. Attempts to bring… CONTINUE READING
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