NUBIScan, an in silico approach for prediction of nuclear receptor response elements.

  title={NUBIScan, an in silico approach for prediction of nuclear receptor response elements.},
  author={Michael Podvinec and Michel Rene Kaufmann and Christoph Handschin and Urs A. Meyer},
  journal={Molecular endocrinology},
  volume={16 6},
Nuclear receptors (NRs) are transcription factors activated by a multitude of hormones, other endogenous substances, and exogenous molecules. These proteins modulate the regulation of target genes by contacting their promoter or enhancer sequences at specific recognition sites. The identification of these response elements is the first step toward detailed insight into the regulatory mechanisms affecting a gene. We have developed NUBIScan, a computer algorithm to predict DNA recognition sites… CONTINUE READING
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