NTRK1 rearrangement in colorectal cancer patients: evidence for actionable target using patient-derived tumor cell line.

@article{Lee2015NTRK1RI,
  title={NTRK1 rearrangement in colorectal cancer patients: evidence for actionable target using patient-derived tumor cell line.},
  author={Su Jin Lee and Gang Li and Seung Tae Kim and Min Eui Hong and Jiryeon Jang and Nara Yoon and Soo Min Ahn and Danielle A. Murphy and Jason H. Christiansen and Ge Wei and Zachary Hornby and Dong Woo Lee and Joon Oh Park and Young Suk Park and Ho-yeong Lim and Sung No Hong and Seok-Hyeong Kim and Wonyoung Kang and Keunchil Park and Woong Yang Park and Kyoung-Mee Kim and Jeeyun Lee},
  journal={Oncotarget},
  year={2015},
  volume={6 36},
  pages={
          39028-35
        }
}
BACKGROUND We have investigated the incidence of NTRK1 rearrangements in metastatic gastrointestinal cancer patients and demonstrated the potential for clinical response of these patients to targeted therapy. METHODS We prospectively collected tumor tissue specimens for one year and simultaneously generated patient-derived tumor cells (PDCs). Specimens were initially screened for TrkA protein expression using TrkA immunohistochemistry (IHC). In the case of TrkA IHC positive results, samples… CONTINUE READING
1
Twitter Mention

Citations

Publications citing this paper.
SHOWING 1-10 OF 15 CITATIONS

Cytoplasmic TrkA Expression as a Screen for Detecting NTRK1 Fusions in Colorectal Cancer12

  • Translational oncology
  • 2018
VIEW 7 EXCERPTS
CITES METHODS
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 19 REFERENCES

Neurotrophins and their receptors: a convergence point for many signalling pathways

MV Chao
  • Nat Rev Neurosci
  • 2003
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Anchored multiplex PCR for targeted next-generation sequencing

  • Nature Medicine
  • 2014
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Similar Papers

Loading similar papers…