NTPase and 5' to 3' RNA duplex-unwinding activities of the hepatitis E virus helicase domain.

@article{Karpe2010NTPaseA5,
  title={NTPase and 5' to 3' RNA duplex-unwinding activities of the hepatitis E virus helicase domain.},
  author={Yogesh A. Karpe and Kavita S. Lole},
  journal={Journal of virology},
  year={2010},
  volume={84 7},
  pages={
          3595-602
        }
}
Hepatitis E virus (HEV) is a causative agent of acute hepatitis, and it is the sole member of the genus Hepevirus in the family Hepeviridae. The open reading frame 1 (ORF1) protein of HEV encodes nonstructural polyprotein with putative domains for methyltransferase, cysteine protease, helicase and RNA-dependent RNA polymerase. It is not yet known whether ORF1 functions as a single protein with multiple domains or is processed to form separate functional units. On the basis of amino acid… CONTINUE READING
BETA

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