NTPDase activity in human lymphocytes is not affected by therapeutic doses of anti-HIV drugs.

@article{Leal2011NTPDaseAI,
  title={NTPDase activity in human lymphocytes is not affected by therapeutic doses of anti-HIV drugs.},
  author={Daniela Bitencourt Rosa Leal and Maria Rosa Schetinger and Cl{\'a}udio Alberto Martins Leal and Cl{\'a}udia de Mello Bertoncheli and Vera M Morsch},
  journal={Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie},
  year={2011},
  volume={65 8},
  pages={594-6}
}
NTPDase (EC 3.6.1.5) is an enzyme that hydrolyzes extracellular nucleoside tri- and/or diphoshates forming AMP that can serve as a substrate for an ecto-5'-nucleotidase (EC 3.1.3.5) with liberation of adenosine, a modulator of vascular tone and inhibitor of platelet aggregation. These enzymes also occur in lymphocytes playing an important role in immune… CONTINUE READING