• Corpus ID: 23591016

NTP technical report on the toxicity studies of 1,6-Hexanediamine Dihydrochloride (CAS No. 6055-52-3) Administered by Drinking Water and Inhalation to F344/N Rats and B6C3F1 Mice.

  title={NTP technical report on the toxicity studies of 1,6-Hexanediamine Dihydrochloride (CAS No. 6055-52-3) Administered by Drinking Water and Inhalation to F344/N Rats and B6C3F1 Mice.},
  author={C. H{\'e}bert},
  journal={Toxicity report series},
  • C. Hébert
  • Published 1 March 1993
  • Medicine
  • Toxicity report series
1,6-Hexanediamine (HDA) is an aliphatic amine that is produced in large volumes in the United States. HDA is widely used as a corrosion inhibitor in lubricants and as an intermediate in the industrial synthesis of paints, resins, inks, and textiles. Toxicity studies of the dihydrochloride salt of HDA (HDDC) were conducted in male and female Fischer 344/N rats and B6C3F1 mice by the drinking water (2-week studies only) and whole-body inhalation routes (2-week and 13-week studies). Animals were… 
1 Citations
Early Toxicology Signal Generation in the Mouse
Performing early signal generation studies in the mouse allows for earlier assessment of the safety liabilities of small molecules, requires significantly less compound, and allows evaluation of more compounds earlier in the project’s life cycle.


Toxicological profile of orally administered 1,6‐hexane diamine in the rat
Dietary administration of HMD to groups of rats for 3 months at dosages of 0, 50, 150, and 500 mg kg−1 resulted in a modest retardation in weight gain at the two higher test levels, but there were no other obvious signs of toxicity or changes in the peripheral blood picture or selected clinical pathology parameters during the study.
The toxicity of dimethylamine in F-344 rats and B6C3F1 mice following a 1-year inhalation exposure.
Pathology of toxic responses to the RD50 concentration of chlorine gas in the nasal passages of rats and mice.
Chlorine-induced severe lesions in specific locations in both the olfactory and respiratory epithelia of the nasal passages with more widespread loss of respiratory and Olfactory cilia are found.
Subchronic inhalation toxicity of hexamethylenediamine in rats.
Four groups of 15 male and 15 female Sprague-Dawley-derived (CD) rats each were exposed to aqueous hexamethylenediamine (HMD) aerosols for 6 hr/day, 5 days/week for 13 weeks at mean analytical
The effects of fasting on the acute oral toxicity of nine chemicals in the rat
Nine chemicals, with a range from extremely to slightly toxic, were used to measure the oral LD50 in both fasted and non‐fasted rats, and the use of non‐ fasted rats in acute oral toxicity determinations allows both the establishment of relative potency and the estimation of dosage levels for further repeated dose oral studies.
Localization of 1,6-[14C]diaminohexane (HMDA) in the prostate and the effects of HMDA on early gestation in Fischer-344 rats.
Of several tissues examined, the highest concentrations of residual radioactivity were found in the prostate at 24 and 72 h post-administration, as well as in the urinary and fecal excretion, respectively.
Pathologic changes following acute methyl isocyanate inhalation and recovery in B6C3F1 mice.
Inhalation studies indicate that methyl isocyanate exposure of mice at or near lethal concentrations causes reversible lesions in the nose and persistent intraluminal and mural fibrosis of the major bronchi.
Biological monitoring of isocyanates and related amines
Two men were exposed to toluene diisocyanate (TDI) atmospheres at three different air concentrations by a gas-phase permeation method, and the exposures were performed in an 8-m3 stainless-steel test chamber, and a connection was observed between concentrations of 2,4- and 2,6-TDI in air and the levels of 1,2- and 1,3-TDA in plasma.
[Effect of various non-radioactive and radioactive chemical compounds on the structure of the spleen].
Dynamical changes in the spleen of mice and rats were studied morphometrically and electron microscopically when the animals were given in drinking water radionucleotides in small concentrations for 1-2 years and at large doses (160-200 rad) atrophy, amyloid degeneration of theSpleen or signs of leukemia were observed.
Respiratory tract lesions induced by sensory irritants at the RD50 concentration.
Findings give additional support to the potential value of the RD50 model for setting occupational exposure guidelines and predicting the risk of injury to the respiratory tract from exposure to airborne sensory irritants.