NT-3 expression from engineered olfactory ensheathing glia promotes spinal sparing and regeneration.

@article{Ruitenberg2005NT3EF,
  title={NT-3 expression from engineered olfactory ensheathing glia promotes spinal sparing and regeneration.},
  author={Marc J. Ruitenberg and Dane B Levison and Seok Voon Lee and Joost Verhaagen and Alan R Harvey and Giles W. Plant},
  journal={Brain : a journal of neurology},
  year={2005},
  volume={128 Pt 4},
  pages={839-53}
}
Adenoviral (AdV) vectors encoding neurotrophin-3 (AdV-NT-3) or the bacterial marker enzyme beta-galactosidase (LacZ gene) were used to transduce olfactory ensheathing glia (OEG) cultures. AdV vector-transduced OEG expressed high levels of recombinant neurotrophin as shown by in situ hybridization and enzyme-linked immunosorbent assay techniques. The biological activity of vector-derived NT-3 was determined in a dorsal root ganglia neurite outgrowth assay. Engineered cell suspensions were then… CONTINUE READING

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