NT-3 and/or BDNF therapy prevents loss of auditory neurons following loss of hair cells.

@article{Staecker1996NT3AB,
  title={NT-3 and/or BDNF therapy prevents loss of auditory neurons following loss of hair cells.},
  author={Hinrich Staecker and R D Kopke and Brigitte Malgrange and Philippe P. Lefebvre and Thomas R. Van De Water},
  journal={Neuroreport},
  year={1996},
  volume={7 4},
  pages={889-94}
}
Destruction of auditory hair cells results in a subsequent loss of auditory neurons. In situ hybridization and neuronal cell culture studies as well as analyses of the inner ears of neurotrophin and neurotrophin receptor gene knockout mice have shown that NT-3 and BDNF mediate both the development and survival of auditory neurons. In this study guinea pigs were exposed to the ototoxic combination of an aminoglycoside antibiotic and a loop diuretic and then received 8 weeks of intracochlear… CONTINUE READING

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