NSs protein of rift valley fever virus promotes posttranslational downregulation of the TFIIH subunit p62.

@article{Kalveram2011NSsPO,
  title={NSs protein of rift valley fever virus promotes posttranslational downregulation of the TFIIH subunit p62.},
  author={Birte Kalveram and Olga A. Lihoradova and Tetsuro Ikegami},
  journal={Journal of virology},
  year={2011},
  volume={85 13},
  pages={6234-43}
}
Rift Valley fever virus (RVFV; family Bunyaviridae, genus Phlebovirus) is an important emerging pathogen of humans and ruminants. Its NSs protein has previously been identified as a major virulence factor that suppresses host defense through three distinct mechanisms: it directly inhibits beta interferon (IFN-β) promoter activity, it promotes the degradation of double-stranded RNA-dependent protein kinase (PKR), and it suppresses host transcription by disrupting the assembly of the basal… CONTINUE READING
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