NSP4 elicits age-dependent diarrhea and Ca(2+)mediated I(-) influx into intestinal crypts of CF mice.

@article{Morris1999NSP4EA,
  title={NSP4 elicits age-dependent diarrhea and Ca(2+)mediated I(-) influx into intestinal crypts of CF mice.},
  author={Andrew P. Morris and Jason K. Scott and Judith M. Ball and Carl Q.-Y. Zeng and Wanda O'neal and Mary K. Estes},
  journal={The American journal of physiology},
  year={1999},
  volume={277 2},
  pages={
          G431-44
        }
}
Homologous disruption of the murine gene encoding the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) leads to the loss of cAMP-mediated ion transport. Mice carrying this gene defect exhibit meconium ileus at birth and gastrointestinal plugging during the neonatal period, both contributing to high rates of mortality. We investigated whether infectious mammalian rotavirus, the recently characterized rotaviral enterotoxin protein NSP4, or its active NSP4(114-135) peptide, can… CONTINUE READING

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