NSF function in neurotransmitter release involves rearrangement of the SNARE complex downstream of synaptic vesicle docking.

@article{Tolar1998NSFFI,
  title={NSF function in neurotransmitter release involves rearrangement of the SNARE complex downstream of synaptic vesicle docking.},
  author={L A Tolar and Leo Pallanck},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1998},
  volume={18 24},
  pages={
          10250-6
        }
}
The SNARE hypothesis has been proposed to explain both constitutive and regulated vesicular transport in eukaryotic cells, including release of neurotransmitter at synapses. According to this model, a vesicle targeting/docking complex consisting primarily of vesicle- and target-membrane proteins, known as SNAREs, serves as a receptor for the cytosolic N-ethylmaleimide-sensitive fusion protein (NSF). NSF-dependent hydrolysis of ATP disassembles the SNARE complex in a step postulated to initiate… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 33 REFERENCES

Assembly and disassembly of a ternary complex of synaptobrevin, syntaxin, and SNAP-25 in the membrane of synaptic vesicles.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 1997
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Redistribution of synaptic vesicles and their proteins in temperature-sensitive shibire(ts1) mutant Drosophila.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 1995
VIEW 11 EXCERPTS
HIGHLY INFLUENTIAL

Neurogenetic studies of ion channels in Drosophila.

  • Ion channels
  • 1992
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Disruption of syntaxin-mediated protein interactions blocks neurotransmitter secretion.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 1997
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Disappearance and reformation of synaptic vesicle membrane upon transmitter release observed under reversible blockage of membrane retrieval.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1989
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL