NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler.

@article{Shen2015NSD3ShortIA,
  title={NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler.},
  author={Chen Shen and Jonathan J Ipsaro and Junwei Shi and Joseph Milazzo and Eric Shing-Suan Wang and J Roe and Yutaka Suzuki and Darryl J. Pappin and Leemor Joshua-Tor and Christopher R Vakoc},
  journal={Molecular cell},
  year={2015},
  volume={60 6},
  pages={847-59}
}
The bromodomain and extraterminal (BET) protein BRD4 is a therapeutic target in acute myeloid leukemia (AML). Here, we demonstrate that the AML maintenance function of BRD4 requires its interaction with NSD3, which belongs to a subfamily of H3K36 methyltransferases. Unexpectedly, AML cells were found to only require a short isoform of NSD3 that lacks the methyltransferase domain. We show that NSD3-short is an adaptor protein that sustains leukemia by linking BRD4 to the CHD8 chromatin remodeler… CONTINUE READING
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