NSC348884, a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis in human cancer cells

@article{Qi2008NSC348884AN,
  title={NSC348884, a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis in human cancer cells},
  author={Wenbo Qi and Kishore Shakalya and Amy E. Stejskal and Adrian Goldman and Saskia Beeck and Laurence Cooke and Daruka Mahadevan},
  journal={Oncogene},
  year={2008},
  volume={27},
  pages={4210-4220}
}
Nucleophosmin (NPM), a multifunctional nucleolar phosphoprotein is dysregulated in human malignancies leading to anti-apoptosis and inhibition of differentiation. We evaluated the precise three-dimensional structure of NPM based on the highly conserved structure of Xenopus NO38 and its requirement to form dimers and pentamers via its N-terminal domain (residues, 1–107). We hypothesized that a small molecular inhibitor (SMI) that could disrupt the formation of dimers would inhibit aberrant NPM… CONTINUE READING