NSAIDs modulate GABA-activated currents via Ca2+-activated Cl− channels in rat dorsal root ganglion neurons

  title={NSAIDs modulate GABA-activated currents via Ca2+-activated Cl− channels in rat dorsal root ganglion neurons},
  author={L. Zhao and L. Li and K. Ma and Y. Wang and J. Li and Wen-Yan Shi and H. Zhu and Zhong-shuang Zhang and J. Si},
  journal={Experimental and Therapeutic Medicine},
  pages={1755 - 1761}
  • L. Zhao, L. Li, +6 authors J. Si
  • Published 2016
  • Chemistry, Medicine
  • Experimental and Therapeutic Medicine
The ability of non-steroidal anti-inflammatory drugs (NSAIDs) to modulate γ-aminobutyrate (GABA)-activated currents via Ca2+-activated Cl- channels in rat dorsal root ganglion neurons (DRG), was examined in the present study. [...] Key Method During the preparation of DRG neurons harvested from Sprague-Dawley rats, the whole-cell recording technique was used to record the effect of NSAIDs on GABA-activated inward currents, and the expression levels of the TMEM16A and TMEM16B subunits were revealed. In the event…Expand
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