NSAIDs induce both necrosis and apoptosis in guinea pig gastric mucosal cells in primary culture.

@article{Tomisato2001NSAIDsIB,
  title={NSAIDs induce both necrosis and apoptosis in guinea pig gastric mucosal cells in primary culture.},
  author={Wataru Tomisato and Shinji Tsutsumi and Kazuhito Rokutan and Tomoko Tsuchiya and Takaaki Mizushima},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2001},
  volume={281 4},
  pages={G1092-100}
}
A major clinical problem encountered with the use of nonsteroidal anti-inflammatory drugs (NSAIDs) such as indomethacin is gastropathy. In this study, we examined, using guinea pig gastric mucosal cells in primary culture, how NSAIDs damage gastric mucosal cells. The short-term treatment of cells with high concentrations of indomethacin decreased cell viability in the absence of apoptotic DNA fragmentation, chromatin condensation, or caspase activation. Cells lost membrane integrity with this… CONTINUE READING