NSAIDs induce apoptosis in nonproliferating ovarian cancer cells and inhibit tumor growth in vivo.

@article{Duncan2012NSAIDsIA,
  title={NSAIDs induce apoptosis in nonproliferating ovarian cancer cells and inhibit tumor growth in vivo.},
  author={Kristal C. Duncan and Henriette Uwimpuhwe and Akos Gabor Czibere and Devanand Sarkar and T. A. Libermann and Paul B Fisher and Luiz F Zerbini},
  journal={IUBMB life},
  year={2012},
  volume={64 7},
  pages={
          636-43
        }
}
Ovarian cancer (OC) is one of the most lethal gynaecological cancers, which usually has a poor prognosis due to late diagnosis. A large percentage of the OC cell population is in a nonproliferating and quiescent stage, which poses a barrier to success when using most chemotherapeutic agents. Recent studies have shown that several nonsteroidal anti-inflammatory drugs (NSAIDs) are effective in the treatment of OC. Furthermore, we have previously described the molecular mechanisms of NSAIDs… CONTINUE READING
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