NSAIDs and the kidney revisited: are selective cyclooxygenase-2 inhibitors safe?

@article{Eras2001NSAIDsAT,
  title={NSAIDs and the kidney revisited: are selective cyclooxygenase-2 inhibitors safe?},
  author={J L Eras and Mark Anthony Perazella},
  journal={The American journal of the medical sciences},
  year={2001},
  volume={321 3},
  pages={181-90}
}
Selective cyclooxygenase-2 (COX-2) inhibitors have provided relief for patients suffering from chronic pain and other inflammatory conditions and have reduced adverse gastrointestinal effects. The documented reduction in gastric erosions, ulcerations, and perforations during the use of COX-2-selective inhibitors raises the question: would the kidney be similarly spared? Our understanding of these enzyme isoforms in the kidney is incomplete. However, kidney tissue seems to possess "constitutive… CONTINUE READING