NSAIDs and kidney.

  title={NSAIDs and kidney.},
  author={P Ejaz and Kaushik Bhojani and Vinay R Joshi},
  journal={The Journal of the Association of Physicians of India},
NSAIDs are commonly used drugs. Even with the advent of selective COX-2 inhibitors, nephrotoxicity still remains a concern. The adverse effects of NSAIDs are mediated via inhibition of prostaglandin synthesis from arachidonic acid by non-specific blocking of the enzyme cyclooxygenase leading to vasoconstriction and reversible mild renal impairment in volume contracted states. When unopposed, this may lead to acute tubular necrosis and acute renal failure. NSAIDs also produce interstitial… CONTINUE READING


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Highly Influential
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