NSAIDs and breast cancer: a possible prevention and treatment strategy.

@article{Agrawal2008NSAIDsAB,
  title={NSAIDs and breast cancer: a possible prevention and treatment strategy.},
  author={Atin Agrawal and Ian S. Fentiman},
  journal={International journal of clinical practice},
  year={2008},
  volume={62 3},
  pages={444-9}
}
CONTEXT Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase (COX) and thereby reduce prostaglandin synthesis. Abnormally upregulated COX and prostaglandins are features of breast cancer so NSAIDs might have a role in treatment and prevention of the disease. OBJECTIVE To review the available epidemiological data on the relation between NSAIDs and risk of breast cancer together with interventional studies in established disease. RESULTS Both case-control and cohort studies… CONTINUE READING

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