NSAID sulindac and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signaling.

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) exert their anticancer effects through cyclooxygenase-2 (COX-2)-dependent and independent mechanisms. Here, we report that Sulindac, an NSAID, induces apoptosis by binding to retinoid X receptor-alpha (RXRalpha). We identified an N-terminally truncated RXRalpha (tRXRalpha) in several cancer cell lines and… (More)
DOI: 10.1016/j.ccr.2010.04.023

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