NSAID-induced gastrointestinal damage and the design of GI-sparing NSAIDs.

  title={NSAID-induced gastrointestinal damage and the design of GI-sparing NSAIDs.},
  author={John L Wallace and Linda Vong},
  journal={Current opinion in investigational drugs},
  volume={9 11},
NSAIDs are among the most widely used medications, but the side effects of these drugs frequently include gastrointestinal (GI) ulceration and bleeding. COX-2 inhibitors were designed that were claimed to be devoid of ulcer-promoting effects; however, this promise has been unfulfilled, and there are concerns about the cardiovascular safety of COX-2 inhibitors. Several novel approaches to developing GI-sparing NSAIDs have been used, with promising preclinical and clinical results. Selective… CONTINUE READING
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