NSAID-associated gastrointestinal damage: methodological considerations and a review of the experience with enteric coated naproxen.

  • Lars Aabakken
  • Published 1992 in European journal of rheumatology and inflammation


Various methods are available for investigating gastrointestinal adverse effects of NSAIDs. Upper endoscopy is regarded a gold standard for controlled studies, but the grading and categorization of the visual impression of mucosal changes is complicated. Faecal blood loss represents another aspect of the toxicity, but quantitative measurements require the… (More)


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