NS1- and minute virus of mice-induced cell cycle arrest: involvement of p53 and p21(cip1).

@article{beeck2001NS1AM,
  title={NS1- and minute virus of mice-induced cell cycle arrest: involvement of p53 and p21(cip1).},
  author={Anne Op de beeck and Jo{\"e}lle Sobczak-Th{\'e}pot and Hueseyin Sirma and Florence Bourgain and Christian Br{\'e}chot and Perrine Caillet-Fauquet},
  journal={Journal of virology},
  year={2001},
  volume={75 22},
  pages={
          11071-8
        }
}
The nonstructural protein NS1 of the autonomous parvovirus minute virus of mice (MVMp) is cytolytic when expressed in transformed cells. Before causing extensive cell lysis, NS1 induces a multistep cell cycle arrest in G(1), S, and G(2), well reproducing the arrest in S and G(2) observed upon MVMp infection. In this work we investigated the molecular mechanisms of growth inhibition mediated by NS1 and MVMp. We show that NS1-mediated cell cycle arrest correlates with the accumulation of the… CONTINUE READING
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