NS-398 upregulates constitutive cyclooxygenase-2 expression in the M-1 cortical collecting duct cell line.

@article{Ferguson1999NS398UC,
  title={NS-398 upregulates constitutive cyclooxygenase-2 expression in the M-1 cortical collecting duct cell line.},
  author={Sandra Ferguson and Richard L. H{\'e}bert and Odette Laneuville},
  journal={Journal of the American Society of Nephrology : JASN},
  year={1999},
  volume={10 11},
  pages={2261-71}
}
The cortical collecting duct (CCD) is a major site of intrarenal prostaglandin E2 (PGE2) synthesis. This study examines the expression and regulation of the prostaglandin synthesizing enzymes cyclooxygenase-1 (COX-1) and -2 in the CCD. By indirect immunofluorescence using isoform-specific antibodies, COX-1 and -2 immunoreactivity was localized to all cell types of the murine M-1 CCD cell line. By immunohistochemistry, both COX-1 and COX-2 were localized to intercalated cells of the CCD on… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

Similar Papers

Loading similar papers…