NS-3 (CG3703), an analog of thyrotropin-releasing hormone, ameliorates cognitive impairment in rats

@article{Ogasawara1995NS3A,
  title={NS-3 (CG3703), an analog of thyrotropin-releasing hormone, ameliorates cognitive impairment in rats},
  author={Takashi Ogasawara and Yojiro Ukai and Masaru Tamura and Kiyoshi Kimura},
  journal={Pharmacology Biochemistry and Behavior},
  year={1995},
  volume={50},
  pages={499-503}
}
The effects of thyrotropin-releasing hormone (TRH) and its analog, N-[[(3R,6R)-6-methyl-5-oxo-thiomorpholinyl] carbonyl]-L-histidyl-L- prolinamide tetrahydrate (NS-3, CG3703) on disturbance of memory of a passive avoidance response (PAR) and an escape response in rats were investigated. NS-3 improved amnesia caused by scopolamine, electroconvulsive shock (ECS), and cycloheximide (CXM), but TRH improved only the ECS-induced amnesia. NS-3 reversed learning deficits caused by hypercapnia, but TRH… CONTINUE READING