NRPD4, a protein related to the RPB4 subunit of RNA polymerase II, is a component of RNA polymerases IV and V and is required for RNA-directed DNA methylation.

@article{He2009NRPD4AP,
  title={NRPD4, a protein related to the RPB4 subunit of RNA polymerase II, is a component of RNA polymerases IV and V and is required for RNA-directed DNA methylation.},
  author={X He and Y. F. Hsu and Olga M F Pontes and Jianhua Zhu and Jian Lu and Ray Anthony Bressan and Craig S. Pikaard and Co-Shine Wang and Jian-Kang Zhu},
  journal={Genes & development},
  year={2009},
  volume={23 3},
  pages={318-30}
}
RNA-directed DNA methylation (RdDM) is an RNAi-based mechanism for establishing transcriptional gene silencing in plants. The plant-specific RNA polymerases IV and V are required for the generation of 24-nucleotide (nt) siRNAs and for guiding sequence-specific DNA methylation by the siRNAs, respectively. However, unlike the extensively studied multisubunit Pol II, our current knowledge about Pol IV and Pol V is restricted to only the two largest subunits NRPD1a/NRPD1 and NRPD1b/NRPE1 and the… CONTINUE READING

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