NRP2 and CD63 Are Host Factors for Lujo Virus Cell Entry.

  title={NRP2 and CD63 Are Host Factors for Lujo Virus Cell Entry.},
  author={Matthijs Raaben and Lucas T. Jae and Andrew S Herbert and Ana I. Kuehne and Sarah H. Stubbs and Yi-Ying Chou and Vincent A Blomen and Tomas Kirchhausen and John M Dye and Thijn R Brummelkamp and Sean P J Whelan},
  journal={Cell host & microbe},
  volume={22 5},
Arenaviruses cause fatal hemorrhagic disease in humans. Old World arenavirus glycoproteins (GPs) mainly engage α-dystroglycan as a cell-surface receptor, while New World arenaviruses hijack transferrin receptor. However, the Lujo virus (LUJV) GP does not cluster with New or Old World arenaviruses. Using a recombinant vesicular stomatitis virus containing LUJV GP as its sole attachment and fusion protein (VSV-LUJV), we demonstrate that infection is independent of known arenavirus receptor genes… CONTINUE READING
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