NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells

@inproceedings{Ratajczak2016NRK1CN,
  title={NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells},
  author={Joanna Ratajczak and Magali Joffraud and Samuel A.J. Trammell and Rosa Ras and N{\'u}ria Canela and Marie Boutant and Sameer S. Kulkarni and Marcelo Teixeira Rodrigues and Philip Redpath and Marie E Migaud and Johan Auwerx and Oscar Yanes and Charles Brenner and Carles Cant{\'o}},
  booktitle={Nature communications},
  year={2016}
}
NAD+ is a vital redox cofactor and a substrate required for activity of various enzyme families, including sirtuins and poly(ADP-ribose) polymerases. Supplementation with NAD+ precursors, such as nicotinamide mononucleotide (NMN) or nicotinamide riboside (NR), protects against metabolic disease, neurodegenerative disorders and age-related physiological decline in mammals. Here we show that nicotinamide riboside kinase 1 (NRK1) is necessary and rate-limiting for the use of exogenous NR and NMN… CONTINUE READING