NRH:quinone reductase 2: an enzyme of surprises and mysteries.

  title={NRH:quinone reductase 2: an enzyme of surprises and mysteries.},
  author={Fanny Vella and Gilles Ferry and Philippe Delagrange and Jean A. Boutin},
  journal={Biochemical pharmacology},
  volume={71 1-2},
Quinone reductase 2 has been discovered in 1961 and rediscovered in 1997. Because of its sequence homology with quinone reductase 1, it has been suspected to detoxify quinones. Ten years later, evidences begin to point to a versatile role of this enzyme. Indeed, QR2 is strongly suspected to be the molecular target of anti-malarian drugs such as chloroquin or paraquine, and of red wine-derived resveratrol that might be responsible for the so-called French paradox. It also is identical to the… CONTINUE READING
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