NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

@article{Dodson2019NRF2PA,
  title={NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis},
  author={M. Dodson and Raul Castro-Portuguez and Donna D. Zhang},
  journal={Redox Biology},
  year={2019},
  volume={23}
}
The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is a key regulator of the cellular antioxidant response, controlling the expression of genes that counteract oxidative and electrophilic stresses. Many pathological conditions are linked to imbalances in redox homeostasis, illustrating the important role of antioxidant defense systems in preventing the pathogenic effects associated with the accumulation of reactive species. In particular, it is becoming increasingly… Expand
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References

SHOWING 1-10 OF 80 REFERENCES
Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration
Transcription Factor Nrf2 Coordinately Regulates a Group of Oxidative Stress-inducible Genes in Macrophages*
  • Tetsuro Ishii, Ken Itoh, +5 authors Masayuki Yamamoto
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 2000
The Roles of NRF2 in Modulating Cellular Iron Homeostasis
Mechanisms of ferroptosis
  • J. Cao, S. Dixon
  • Biology, Medicine
  • Cellular and Molecular Life Sciences
  • 2016
Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis
Glutaminolysis and Transferrin Regulate Ferroptosis.
Ferroptosis
...
1
2
3
4
5
...