NRF2, cancer and calorie restriction


The transcription factor NF-E2-related factor (NRF2) is a key regulator of several enzymatic pathways, including cytoprotective enzymes in highly metabolic organs. In this review, we summarize the ongoing research related to NRF2 activity in cancer development, focusing on in vivo studies using NRF2 knockout (KO) mice, which have helped in defining the crucial role of NRF2 in chemoprevention. The lower cancer protection observed in NRF2 KO mice under calorie restriction (CR) suggests that most of the beneficial effects of CR on the carcinogenesis process are likely mediated by NRF2. We propose that future interventions in cancer treatment would be carried out through the activation of NRF2 in somatic cells, which will lead to a delay or prevention of the onset of some forms of human cancers, and subsequently an extension of health- and lifespan.

DOI: 10.1038/onc.2010.492

4 Figures and Tables

Citations per Year

255 Citations

Semantic Scholar estimates that this publication has 255 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{MartnMontalvo2011NRF2CA, title={NRF2, cancer and calorie restriction}, author={Alejandro Mart{\'i}n-Montalvo and J. M. Villalba and Pl{\'a}cido Navas and Rafael de Cabo}, journal={Oncogene}, year={2011}, volume={30}, pages={505-520} }