NRF2 blockade suppresses colon tumor angiogenesis by inhibiting hypoxia-induced activation of HIF-1α.

@article{Kim2011NRF2BS,
  title={NRF2 blockade suppresses colon tumor angiogenesis by inhibiting hypoxia-induced activation of HIF-1α.},
  author={Tae-Hyoung Kim and Eu-gene Hur and S Kang and Jung-Ae Kim and Dinesh Kumar Thapa and You Mie Lee and Sae Kwang Ku and Yunjin Jung and Mi-Kyoung Kwak},
  journal={Cancer research},
  year={2011},
  volume={71 6},
  pages={
          2260-75
        }
}
Transcription factor NRF2 is an important modifier of cellular responses to oxidative stress. Although its cytoprotective effects are firmly established, recent evidence suggesting important roles in cancer pathobiology has yet to be mechanistically developed. In the current study, we investigated the role of NRF2 in colon tumor angiogenesis. Stable RNAi-mediated knockdown of NRF2 in human colon cancer cells suppressed tumor growth in mouse xenograft settings with a concomitant reduction in… CONTINUE READING

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