NRF2 and p53: Januses in cancer?

@inproceedings{Rotblat2012NRF2AP,
  title={NRF2 and p53: Januses in cancer?},
  author={Barak Rotblat and Gerry Melino and Richard A Knight},
  booktitle={Oncotarget},
  year={2012}
}
The transcription factor nuclear factor (erythroid-derived 2)-like 2, also known as NFE2L2 or NRF2, is a master regulator of the anti-oxidative stress response and positively controls the expression of a battery of anti-oxidative stress response proteins and enzymes implicated in detoxification and glutathione generation. Although its detoxifying activity is important in cancer prevention, it has recently been shown that cancer cells also exploit its protective functions to thrive and resist… CONTINUE READING
Highly Cited
This paper has 70 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

70 Citations

01020'14'16'18
Citations per Year
Semantic Scholar estimates that this publication has 70 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 176 references

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function.

Proceedings of the National Academy of Sciences of the United States of America • 2010
View 4 Excerpts
Highly Influenced

Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin.

The Journal of pathology • 2010
View 10 Excerpts
Highly Influenced

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy.

Proceedings of the National Academy of Sciences of the United States of America • 2008
View 9 Excerpts
Highly Influenced

Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid.

Proceedings of the National Academy of Sciences of the United States of America • 2004
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…