NRF2 activates a partial epithelial-mesenchymal transition and is maximally present in a hybrid epithelial/mesenchymal phenotype

@inproceedings{Bocci2019NRF2AA,
  title={NRF2 activates a partial epithelial-mesenchymal transition and is maximally present in a hybrid epithelial/mesenchymal phenotype},
  author={Federico Bocci and Satyendra C Tripathi and Samuel A Vilchez Mercedes and Jason T George and Julian P Casabar and Pak Kin Wong and Samir M Hanash and Herbert Levine and Jos{\'e} N. Onuchic and Mohit Kumar Jolly},
  booktitle={Integrative biology : quantitative biosciences from nano to macro},
  year={2019}
}
The epithelial-mesenchymal transition (EMT) is a key process implicated in cancer metastasis and therapy resistance. Recent studies have emphasized that cells can undergo partial EMT to attain a hybrid epithelial/mesenchymal (E/M) phenotype - a cornerstone of tumour aggressiveness and poor prognosis. These cells can have enhanced tumour-initiation potential as compared to purely epithelial or mesenchymal ones and can integrate the properties of cell-cell adhesion and motility that facilitates… CONTINUE READING

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