NRF2 Pathway Activation and Adjuvant Chemotherapy Benefit in Lung Squamous Cell Carcinoma

@article{Cescon2015NRF2PA,
  title={NRF2 Pathway Activation and Adjuvant Chemotherapy Benefit in Lung Squamous Cell Carcinoma},
  author={D. Cescon and D. She and S. Sakashita and Chang-Qi Zhu and M. Pintilie and F. Shepherd and M. Tsao},
  journal={Clinical Cancer Research},
  year={2015},
  volume={21},
  pages={2499 - 2505}
}
Purpose: Genomic profiling of lung squamous cell carcinomas (SCC) has identified NRF2 pathway alterations, which activate oxidative response pathways, in one third of tumors. Preclinical data suggest these tumors may be resistant to platinum-based chemotherapy. We evaluated the clinical relevance of these findings and assessed whether NRF2 activation predicts benefit from adjuvant chemotherapy in SCC. Experimental Design: Logistic regression (LR) and significance analysis of microarrays (SAM… Expand
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