NRBP2 Overexpression Increases the Chemosensitivity of Hepatocellular Carcinoma Cells via Akt Signaling.

@article{Zhang2016NRBP2OI,
  title={NRBP2 Overexpression Increases the Chemosensitivity of Hepatocellular Carcinoma Cells via Akt Signaling.},
  author={Lixing Zhang and Chao Ge and Fangyu Zhao and Yang Zhang and Xin Wang and Ming Yao and Jinjun Li},
  journal={Cancer research},
  year={2016},
  volume={76 23},
  pages={
          7059-7071
        }
}
Hepatocellular carcinoma is highly resistant to chemotherapy. Research data supported that cancer stem cells (CSC) may be responsible for the chemoresistance and strategies that suppress CSCs stemness could also inhibit the drug resistance. In this study, we found that nuclear receptor binding protein 2 (NRBP2) expression was downregulated in the CD133+ hepatocellular carcinoma CSCs. Most adjacent noncancerous liver tissue analyzed expressed higher level of NRBP2 compared with cancerous tissue… CONTINUE READING

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