NRAS mutation causes a human autoimmune lymphoproliferative syndrome.


The p21 RAS subfamily of small GTPases, including KRAS, HRAS, and NRAS, regulates cell proliferation, cytoskeletal organization, and other signaling networks, and is the most frequent target of activating mutations in cancer. Activating germline mutations of KRAS and HRAS cause severe developmental abnormalities leading to Noonan, cardio-facial-cutaneous… (More)


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@article{Oliveira2007NRASMC, title={NRAS mutation causes a human autoimmune lymphoproliferative syndrome.}, author={Joao M. B. Oliveira and Nicolas Bid{\`e}re and Julie E. Niemela and Lixin Zheng and Keiko Sakai and Cynthia P Nix and Robert L. Danner and Jennifer Joanna Barb and Peter J. Munson and Jennifer M Puck and Janet Dale and Stephen E. Straus and Thomas A. Fleisher and Michael J Lenardo}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2007}, volume={104 21}, pages={8953-8} }