NRAMP1 gene polymorphisms in patients with rheumatoid arthritis.

  title={NRAMP1 gene polymorphisms in patients with rheumatoid arthritis.},
  author={Dharam P. Singal and Jingbo Li and Y. H. Zhu and G Zhang},
  journal={Tissue antigens},
  volume={55 1},
Rheumatoid arthritis (RA) is a chronic inflammatory joint disease associated with HLA-DR genes that share amino acid sequence motif QKRAA/QRRAA from position 70 to 74 in the third hypervariable region of DR1 molecule. The contribution of HLA in RA is however about 37%, suggesting a role for other genes. One such candidate is the gene that encodes natural resistance-associated macrophage protein (NRAMP1), which plays a crucial role in inflammation and tissue destruction. In the present study, we… CONTINUE READING