NRAMP1 (SLC11A1) gene polymorphisms that correlate with autoimmune versus infectious disease susceptibility in tuberculosis and rheumatoid arthritis.

@article{Ates2009NRAMP1G,
  title={NRAMP1 (SLC11A1) gene polymorphisms that correlate with autoimmune versus infectious disease susceptibility in tuberculosis and rheumatoid arthritis.},
  author={Omer Faruk Ates and Levent Dalyan and Benan M{\"u}sellim and Gulen Hatemi and Hande T{\"u}rker and Gul Ongen and Vedat Hamuryudan and Aysegul Topal-Sarikaya},
  journal={International journal of immunogenetics},
  year={2009},
  volume={36 1},
  pages={15-9}
}
NRAMP1 gene has multiple pleiotropic effects on macrophage activation pathways. These pleiotropic effects may increase resistance to infections such as tuberculosis (TB), but may also lead to susceptibility of autoimmune diseases such as rheumatoid arthritis (RA). It has been hypothesized that allele 3 would be associated with autoimmune diseases, whereas allele 2 would be associated with infectious diseases, and genetic factors that enhanced survival in the epidemics of TB might have led to… CONTINUE READING
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