NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection.

@article{Volakakis2010NR4AON,
  title={NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection.},
  author={Nikolaos Volakakis and Banafsheh Kadkhodaei and Eliza Joodmardi and Karin Wallis and Lia Panman and Jessica M. Silvaggi and Bruce M. Spiegelman and Thomas Perlmann},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 27},
  pages={12317-22}
}
Induced expression of neuroprotective genes is essential for maintaining neuronal integrity after stressful insults to the brain. Here we show that NR4A nuclear orphan receptors are induced after excitotoxic and oxidative stress in neurons, up-regulate neuroprotective genes, and increase neuronal survival. Moreover, we show that NR4A proteins are induced by… CONTINUE READING